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BACKGROUND
Proton therapy may reduce cognitive deficits after radiotherapy among brain tumor survivors, although current data are limited to retrospective comparisons between historical cohorts. The authors compared intelligence quotient scores within a case‐matched cohort of children with medulloblastoma treated with proton radiation (PRT) or photon radiation (XRT) over the same time period.
METHODS...
BACKGROUND
The IBIS/Tyrer‐Cuzick model is used clinically to guide breast cancer screening and prevention, but was developed primarily in non‐Hispanic White women. Little is known about its long‐term performance in a racially/ethnically diverse population.
METHODS
The Women's Health Initiative study enrolled postmenopausal women from 1993‐1998. Women were included who were aged <80 years at...
BACKGROUND
Racial and ethnic minority children with cancer disproportionately receive intensive care at the end of life (EOL). It is not known whether these differences are goal‐concordant or disparities. The authors sought to explore patterns of pediatric palliative care (PPC) and health care utilization in pediatric oncology patients receiving subspecialty palliative care at the end‐of‐life (last...
Background
Children, adolescents, and young adults with hematologic malignancies tend to receive high‐intensity end‐of‐life care (HI‐EOLC), but sociodemographic and hospital‐based predictors of HI‐EOLC remain unclear.
Methods
The authors conducted a population‐based, retrospective cohort study with the Premier Healthcare Database. They identified individuals with hematologic malignancies who were...
Background
Obesity is a chronic, relapsing, and progressive disease; it is associated with poor health‐related quality of life (HRQOL) in survivors of breast cancer.
Methods
In this 2 × 2 factorial trial, 351 survivors of breast cancer with overweight or obesity were randomized to 1 of 4 treatment groups for 52 weeks: control, exercise alone, diet alone, or exercise plus diet. HRQOL end points...
Background
The purpose of this study was to examine the health‐related quality of life of sexual minority survivors in comparison with heterosexual survivors.
Methods
Four hundred eighty eligible survivors participated in a telephone survey that measured survivors' outcomes, which consisted of physical and mental quality of life and self‐rated fair or poor health. These survivors were diagnosed...
18F‐fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is now an integral part of lymphoma staging and management. Because of its greater accuracy compared with CT alone, PET/CT is currently routinely performed for staging and for response assessment at the end of treatment in the vast majority of FDG‐avid lymphomas and is the cornerstone of response classification...
BACKGROUND
High‐dose chemotherapy (HDCT) plus peripheral blood stem cell transplantation (PBSCT) is effective salvage therapy for relapsed metastatic germ cell tumors (GCTs) but has potential toxicity. Historically, an age of ≥40 years has been associated with greater toxicity and worse outcomes.
METHODS
This is a retrospective analysis of 445 consecutive patients with relapsed GCT treated with...
Background
Poor mercaptopurine (6MP) adherence (mean adherence rate < 90%) increases the relapse risk among children with acute lymphoblastic leukemia (ALL). 6MP adherence remains difficult to measure in real time. Easily measured patient‐level factors could identify patients at risk for poor adherence.
Methods
The authors measured 6MP adherence via electronic monitoring for 6 months per patient...
BACKGROUND
During the past 4 decades, there has been a growing focus on preserving the fertility of patients with childhood cancer; however, no large studies have been conducted of live births across treatment decades during this period. Therefore, the authors estimated the potential birth deficit in female childhood cancer survivors and the probability of live births.
METHODS
In total, 8886 women...
Background
Social needs are actionable mediators of social determinants of health. Along with distress, they affect quality of life and survival in patients with cancer. The objectives of this study were to identify the most common social needs and distress in a largely immigrant gynecologic oncology patient population at a public safety‐net hospital and to evaluate for specific needs associated...
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